|The Collaborative Study on the Genetics of Alcoholism (COGA) is a
multi-site, multi-disciplinary undertaking with the overall goals of characterizing the
familial transmission of alcoholism and related phenotypes and identifying susceptibility
genes using genetic linkage. The study is being coordinated by the SUNY Downstate
Medical Center in Brooklyn and has four Co-Principal Investigators: B. Porjesz, V.
Hesselbrock, H. Edenberg, and L. Bierut. COGA includes nine different centers where
data collection, analysis, and storage take place. The nine sites and Principal
Investigators and Co-Investigators are: University of Connecticut (V. Hesselbrock);
Indiana University (H.J. Edenberg, J. Nurnberger Jr., T. Foroud); University of Iowa (S.
Kuperman); SUNY Downstate (B. Porjesz); Washington University in St. Louis (L. Bierut, A.
Goate, J. Rice); University of California at San Diego (M. Schuckit); Howard University
(R. Taylor); Rutgers University (J. Tischfield); Southwest Foundation (L. Almasy).
Zhaoxia Ren serves as the NIAAA Staff Collaborator. This national
collaborative study is supported by the NIH Grant U10AA008401 from the National Institute
on Alcohol Abuse and Alcoholism (NIAAA)
and the National Institute on Drug Abuse (NIDA).
Interviewing and testing of COGA
families is conducted at seven university centers: SUNY Downstate Medical
Center in Brooklyn, University of Connecticut, Indiana University, University of Iowa,
University of California in San Diego, Howard University in Washington, D.C., and
Washington University in St. Louis. All seven sites will carry out the identical
study protocol. Most of these institutions continue to be responsible for
maintaining scientific and procedural standards as well as quality control in their areas
of expertise including Ascertainment, Psychiatric Assessment, Neurophysiology, Molecular
Biology, and Genetic Analyses. The scope and scale of COGA also necessitates a
complex data management system. The data management and repository functions are
shared based on specialty by Washington University (clinical), Indiana University
(pedigree), and SUNY (electrophysiology). Washington University doubles as the
overall data management and repository coordinating center. In addition, a cell and
DNA repository will be managed by Jay Tischfield now at Rutgers University.