COGA Families (Distribution 2.0)

DESCRIPTIVE INFORMATION BY DIAGNOSTIC MODEL

' M1 M2 M3
PEDIGREES WITH AN AFFECTED SIB-PAIR WITH DNA AVAILABLE      
# sibships, 2 affected sibs with DNA available 148 131 106
# sibships, 3 affected sibs with DNA available 82 65 40
# sibships, 4 affected sibs with DNA available 29 21 11
# sibships, 5 or more affected sibs with DNA available 13 7 1
Total # pedigrees,at least 1 affected sib-pair with DNA available 236 199 151
# affected sib-pairs with DNA available (n-1) 458 354 223
Maximum # affected sib-pairs with DNA available [n*(n-1)/2] 736 532 302
# affected sibs with DNA available 730 578 381
# other affected relatives with DNA available 217 165 107
Total # affecteds with DNA available 947 743 488
# unaffected sibs with DNA available 357 342 274
# other unaffected relatives with DNA available 787 719 646
Total # subjects with DNA available 2E3 2E3 1E3
# sibships, no parent with DNA available 51 42 25
# sibships, 1 parent with DNA available 83 71 53
# sibships, both parents with DNA available 138 111 80
# afffecteds with DNA available, by sex      
Female 313 256 159
Male 634 487 329
PEDIGREES WITHOUT AN AFFECTED SIB-PAIR WITH DNA AVAILABLE      
# pedigrees, one affected with DNA available 10 25 60
# pedigrees, 2 affecteds with DNA available 13 30 35
# pedigrees, 3 affecteds with DNA available 1 3 5
# pedigrees, 4 affecteds with DNA available 0 2 0
Total # pedigrees, at least 1 affected with DNA available 24 60 100
Total # affecteds with DNA available 39 102 145
Total # subjects with DNA available 89 376 772
TRIOS FOR ASSOCIATION ANALYSIS      
(AN AFFECTED INDIVIDUAL + 2 PARENTS WITH DNA AVAILABLE)      
# pedigrees containing at least 1 trio 151 149 131

MODEL 1: DSM-III-R + Feighner

MODEL 2: DSM-IV

MODEL 3: ICD-10