Alcoholism exacts a heavy toll on our society, not only on affected
individuals and their families, but also through the lost workplace productivity,
violence, traffic injuries and fatalities, and increased burden on our medical care system
resulting directly or indirectly from the abuse of alcohol associated with alcoholism. In
order to identify genes influencing susceptibility to this genetically complex disorder,
the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has supported the
Collaborative Studies on Genetics of Alcoholism (COGA) since 1989.
The COGA investigators have mapped several loci linked to alcoholism at
the suggestive level of statistical significance, and are currently attempting to identify
the genes responsible for these linkage findings. (You will find a list of COGAs
publications elsewhere on this website.) COGAs efforts have resulted in the creation
of a set of clinical, diagnostic and genetic data and a repository of cell lines from more
than three thousand members of families ascertained through a member affected with
alcoholism. These data and cell lines should be a valuable resource for elucidating the
genetics of alcoholism. NIAAA and the COGA investigators are pleased to make available to
qualified investigators the clinical and genetic datafiles and the DNA samples and cell
lines maintained by the COGA Distribution Centers.
We hope that your work with the NIAAA/COGA DNA samples and data will lead
to future advances in our understanding of the biological bases of alcoholism, and help to
alleviate the suffering of all those in our society whose lives have been impacted by this
disease. For further information, please visit our website at http://www.niaaa.nih.gov.
T. K. Li, M.D.